Janus surfaces present technological opportunities both for research and industry in which different chemical, physical and/or structural components need to coexist for a single purpose such as chemistry, textile and material science. Varying inorganic and organic (polymer-based) materials are conventionally used however, utilizing nature-derived polymers to fabricate Janus structures is a recent and attractive trend which makes them more applicable for bio-based treatments with environmental concerns. Particularly, promising applications of Janus structures as being surfactants, drug delivery and micro/nano encapsulation vehicles for biomedical purposes successfully forward the interest on Janus concept to the food related practices. Producing Janus structures from nature-derived and food grade polymers such as alginate, cellulose, chitosan, lipid nanocrystals, zein and some plant-proteins and their usage stronger emulsions with higher stabilities, biosensing or antimicrobial practices as well as bioactive delivery and release control might be considered as a new era for food processing industry.